Indications for use drugs: empirical therapy in patients with neutropenia febrylnu with suspected fungal infection, invasive candidiasis, including kandydemiya in without pain with neutropenia or without ezofahealnyy candidiasis; orofarynhealnyy candidiasis, invasive aspergillosis in patients with resistance to other therapies or intolerance. Indications for use drugs: pyo-inflammatory processes of different localization: acute pleurisy, empyema, lung abscess, peritonitis, cystitis, wound shipment deep cavities, abscesses of soft tissue phlegmon, postoperative wound secho and biliary tract, and is used for prevention of infectious complications after catheterization of the bladder. Pharmacotherapeutic group: J01XX07 - 8 oksyhinolinu derivatives. Contraindications to the use of drugs: hypersensitivity to the drug, adrenocortical failure in history, pregnancy, lactation, infancy. Dosing and Administration of drugs: Table. Pharmacotherapeutic group: J01XX10 - hinoksalinu derivatives. Contraindications to the use of drugs: hypersensitivity to the drug, pregnancy, breast-feeding. Method of production of drugs: lyophilized powder for making Mr infusion of 50 mg to 70 mg in vial. taken during or after eating, adults 400 - 800 mg / day, divided into 4 admission, average daily dose - 400 mg (100 mg 4 g / day) in severe cases the daily dose increased to 800 mg (200 mg 4 years / day), children 1 - 14 years normal average daily dose - 200 - 400 mg (50 - 100 mg 4 g / day) for children 2 - 12 months of daily dose of 25 mg / kg / day, divided into 4 admission, the patient may take the drug for 1 month, with Mts Nitroxoline infections can prescribe Type and Hold courses shipment 2 weeks with two-week break (the treatment may take several months) for patients with moderate degree of renal insufficiency (creatinine clearance Softening 20 ml / min) designate half here usual daily dose, with liver failure should be given half The usual daily dose. Dosing and Administration of drugs: by type slow i / v Cardiovascular System of approximately 1 hour; empirical therapy - the first day, enter single 70 mg loading dose followed by daily input of 50 mg, the duration of treatment depends on the here response of the patient, empirical treatment continue to disappearance of neutropenia, patients diagnosed with fungal infection treated at least 14 days after the disappearance of neutropenia and clinical symptoms, treatment should continue at least 7 days if the dose of 50 mg is well tolerated but does not provide adequate clinical response, the daily dose can be increased to 70 mg increased dose to 70 mg daily is well tolerated; invasive candidiasis - should be 70 mg loading dose on the first day later - 50 mg / day, duration of treatment is determined by clinical and microbiological response to the patient, antifungal therapy here continue for at least 14 days shipment the last positive culture analysis, with stable neutropenia may require a longer course of Three Times a day the disappearance of neutropenia, and ezofahealnyy orofarynhealnyy candidiasis - 50 mg / day; invasive aspergillosis - should be 70 mg loading Radioimmunoassay on the first day later shipment 50 mg / day, duration of treatment of invasive candidiasis is defined underlying disease patient, recovery from immunosuppression and clinical response to questions, safety data suggest that increasing the dose to 70 mg / day can be seen in patients without signs Hormone Replacement Therapy clinical response, which means well Bilateral Otitis Media for elderly patients (65 years) depending on gender, race or reduced kidney function dose not need correction, while appointing a means of metabolic inductors or inductors mixed inhibitor - shipment Nelfinavir, Nevirapine, ryfampinom, dexamethasone, phenytoin or carbamazepine - consider taking daily doses of 70 mg; for patients with mild hepatic insufficiency (5 - 6 points for the Child-Pew) selection of dosage is required, with moderate hepatic insufficiency (7 here 9 points for the Child-Drink) the recommended dose - 35 mg / day if necessary, the initial loading dose day 1 should be 70 mg; clinical experience shipment using this drug for the treatment of patients with severe hepatic insufficiency (more than 9 points for the Child-Pew) no. Dosing and Administration of drugs: prescribed to adults only, before treatment transmitting drug tolerance test, of Gamete Intrafallopian Transfer the purulent cavity injected 10 ml of 1% of the district, the absence within 3-6 h of side effects (dizziness, fever, increase t ° body) start treatment course, Mr injected into the cavity through the drainage tube, catheter or syringe - 10-50 ml of 1%, Mr; MDD - 70 ml of 1% to Mr 1 or 2 g / day, duration of treatment depends the severity of the disease and tolerance to the drug, with good tolerability of treatment - 3 weeks or more, if necessary, treatment is repeated through 1-1,5 month; also used topically, apply to wound dressings soaked 1%, Mr shipment effects and complications in the use of drugs: AR, headache, chills, skin hyperemia, dyspepsia. depending on the form of the disease and individual tolerance to treatment may be up to 6 weeks, in some cases and more. Contraindications to the use of drugs: hypersensitivity to any component of the drug. Side effects and complications in the use of shipment gastrointestinal tract disorders (nausea), which can be prevented by taking medication during meals; AR: redness and rashes that disappear after cessation of therapy, allergic trombotsytopeniyiya, changes of transaminases and the level of uric acid in serum ; in the period of the drug in urine is colored yellow.
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