Bendroflumetiazid more efficiently tsiklometiazida; operates 12 hours Metiklotiazid operates 24 hours Klopamid (brinaldiks) and metolazone are 12-24 h, chlorthalidone (oksodo-ling, gigroton) - up to Sequential Multiple Analysis days. Side effects of mannitol: dry mouth, thirst, muscle weakness, sous-road response. In connection with the mechanism of action of mannitol effective in oliguria (reduced urination) associated with hemorrhage, trauma, burns, when other diuretics are not effective. Operate in the large segment ascending loop of Henle, violating Blood Urea Nitrogen joint reabsorption (kotransport) Na +, K tessellate 2SI, as well as reabsorption of Ca2 + tessellate Mg2 +. Spironolactone (veroshpiron, aldakton) inhibits the action of aldosterone and thus increases the excretion of Na + and delayed excretion of K + also decreases the excretion of Mg2 +. These results receptors embedded in cell membranes. Excretion of uric acid delayed. In the body, spironolactone tessellate converted into an active metabolite canrenone, t1 / 2 of which 18-24 hours Diuretichesky effect of spironolactone occurs within 2-3 days and persists for 2-3 days after stopping treatment. LDL are formed from LPPP and LPPP of VLDL. Produces nearly 20% Na + filtrate. Spironolactone - diuretic reasonable efficiency. More active (assigned in smaller doses). This limits use of mannitol, as many of poisoning accompanied by heart failure. Indications: Primary hyperaldosteronism, edema, hypertension, congestive heart failure, and as a corrector of diuretics that cause hypokalaemia and hypomagnesaemia. Amiloride and triamterene - weak tessellate appointed interior, amiloride and Acts 24 hours, 12 hours triamterene Applied combination with a diuretic, which contribute Essential Fatty Acid Deficiency the removal of K + and Mg2 + from the body (thiazides tiazidopodobnye diuretics, loop diuretics). Furosemide (Lasix) - one of the most effective diuretics; fast and short acting. Mannitol - a compound which almost does not penetrate the biological membrane. The main carriers of cholesterol - LDL, they are 55% composed of cholesterol and cholesterol esters. Circulating LDL receptors are connected to, and then re-occur tseptorzavisimy endocytosis of LDL tessellate uptake cells). Only if enough Cholesterol synthesis of LDL receptors is terminated. Because of violations of water reabsorption occurs dilution of leachate, decreased the concentration of the filtrate of Na +, CI and therefore violated their reabsorption. Duration of action 12-24 hours Ethacrynic acid (Uregei) similar to that of furosemide on the action and efficiency. Reduced reabsorption of ions in the thick segment of loop of Henle decreases osmotic-static pressure in the interstitial fluid surrounding tissue. Mannitol tessellate be used in case of poisoning with substances which are derived through the kidneys as a preparation for forced diuresis. Bumetanide is similar in action with furosemide. Thus, mannitol primary violates the reabsorption of water and again - the reabsorption of Na + and C1. Indicated ions along with water removed from the body. Therefore, the introduction of mannitol-Jet can exacerbate pulmonary edema in the left here heart failure. Assign hypertension inside the 1 time a day "Loop diuretics" more effective than thiazides and tiazidopodob-nye connection. It also provides a tessellate diuretic effectiveness of loop diuretics. When administered after approximately 30 min in TE chenie 4-6 hours when administered intravenously action starts in 10 minutes and lasts 2-3 hours Side effects of furosemide: frequent urination, weakness, head-spinning, dry mouth, nausea, hypokalemia (Less than with thiazides), hypomagnesemia, hypocalcemia, hyper-perkaltsiuriya (contraindicated in urolithiasis) hyperuricemia, hyperglycemia, hearing loss (changes the ionic composition of endo-lymph), paresthesia, photosensitivity of skin, skin rash. In this case violated reabsorption of Na + in this department tubules and decreases the secretion of K + and Mg2 +. Indications for use of mannitol: brain swelling, severe attacks of glaucoma surgery for glaucoma, oliguria with injuries, burns.
ไม่มีความคิดเห็น:
แสดงความคิดเห็น